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Spice is a fictional drug in Tom Clancy's The Division 2. Throughout Washington, D.C., players will find drug labs, drug-making paraphernalia and chemicals used by the Hyenas faction.

The drug seems to have brief human-enhancing properties that enable the Hyenas to deny pain, increasing their health and speed. It also, however, makes the Hyenas the most aggressive and less tactical faction of D.C.

When presumably snorted through a gas mask, it gives enhanced health and removes pain inhibitors, however if consumed any other way, causes confusion and disorientation.

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